Overview

Olkem Trio is a three-drug combination (Olmesartan Medoxomil + Cilnidipine + Chlorthalidone) used to treat hypertension (high blood pressure) when single-drug therapy is ineffective. It helps lower blood pressure, reducing the risk of heart attack, stroke, and kidney problems.

Key Components & Mechanism of Action

1. Olmesartan Medoxomil (ARB) – Blocks angiotensin II receptors, relaxing blood vessels.

2. Cilnidipine (CCB) – Inhibits calcium channels, dilating blood vessels.

3. Chlorthalidone (Diuretic) – Removes excess water/sodium, reducing blood volume.

Combined Effect: Lowers blood pressure by relaxing blood vessels and increasing urine output.

Dosage & Administration

• Available Strengths:

  • Olkem Trio 6.25 Tablet (Lower dose)

  • Olkem Trio 40 Tablet (Higher dose)

• How to Take:

  • Swallow whole with food (do not crush/chew).

  • Take at the same time daily for consistency.

  • Avoid taking within 4 hours of bedtime (due to diuretic effect).

• Missed Dose: Take as soon as remembered, but skip if close to the next dose. Do not double dose.

Benefits

• Long-term blood pressure control (prevents complications like stroke/heart attack).

• No immediate symptom relief (hypertension is often asymptomatic).

• Effective when single-drug therapy fails.

Side Effects

Most are mild and temporary, but consult a doctor if persistent:

• Common:

  • Ankle swelling, headache, dizziness, fatigue.

  • Palpitations, sleepiness, taste changes.

  • Upset stomach, flushing, vertigo.

• Metabolic Effects:

  • Increased uric acid, glucose intolerance, altered lipids.

Precautions & Warnings

Monitoring Requirements

Regular check-ups for:

• Blood pressure

• Kidney function

• Electrolytes (potassium, sodium)

• Blood sugar & uric acid levels

Conclusion

Olkem Trio is an effective triple-combination therapy for resistant hypertension but requires careful monitoring due to potential side effects and interactions. Always follow doctor’s instructions and report any unusual symptoms.