Product Description

Tolkem SR 450 Tablet, manufactured by Alkem Pharma, contains Tolvaptan (450mg, SR), a vasopressin receptor antagonist. It is prescribed for patients with hyponatremia (low sodium levels) and fluid retention due to heart failure, liver cirrhosis, or kidney diseases.

The sustained-release (SR) formulation ensures a gradual and prolonged effect, helping maintain sodium levels and reduce swelling over a longer period. Tolkem SR 450 aids in balancing fluids in the body and improves symptoms such as shortness of breath, edema, and bloating.

Uses

• Treatment of hyponatremia (low sodium levels)

• Manages fluid retention in heart failure patients

• Reduces swelling due to liver cirrhosis or kidney disorders

• Supports overall fluid and electrolyte balance

Key Benefits

• Sustained-release action for longer-lasting effect

• Corrects sodium imbalance in the body

• Reduces edema and fluid retention

• Supports cardiovascular, liver, and kidney health

How to Use

• Take the tablet orally with water, usually once daily or as prescribed by your doctor.

• Can be taken with or without food.

• Follow the dosage instructions carefully; do not change dose without consulting your doctor.

How It Works

• Tolvaptan blocks the action of vasopressin, a hormone that causes water retention.

• Promotes excretion of excess water while maintaining sodium balance.

• Helps restore fluid and electrolyte balance and reduces swelling.

Side Effects

• Increased thirst or dry mouth

• Frequent urination

• Nausea, headache, or dizziness

• Fatigue or mild weakness

• Rarely, liver enzyme changes

Precautions & Warnings

• Not suitable for patients with severe kidney disease or inability to urinate.

• Avoid dehydration and maintain adequate fluid intake as advised.

• Inform your doctor about any liver, heart, or kidney problems.

• Regular monitoring of sodium levels and liver function is essential.

• Pregnant or breastfeeding women should consult a doctor before use.

Storage Instructions

• Store in a cool, dry place, away from sunlight and moisture.

• Keep out of reach of children.

FAQs

What conditions is Tolkem SR 450 used for?

It is used for low sodium levels and fluid retention in heart, liver, or kidney disorders.

Can it be taken with food?

Yes, Tolkem SR 450 can be taken with or without food.

What if I miss a dose?

Take it as soon as you remember. If it is near the time of the next dose, skip the missed one. Do not double the dose.

Can it affect liver function?

Rarely, it may cause liver enzyme changes, so monitoring is advised.

Is Tolkem SR 450 safe for long-term use?

Yes, under medical supervision with regular monitoring of sodium and liver function.