Daparyl-VM 500 Tablet

Description

Product Description

Daparyl-VM 500mg Tablet brings together three antidiabetic medicines that lower blood glucose through different pathways. Each tablet contains Dapagliflozin 10 mg, Metformin Hydrochloride 500 mg and Vildagliptin 100 mg. Intas Pharmaceuticals Ltd. markets the formulation in India.

The combination may be prescribed when more than one mechanism is needed to achieve appropriate blood-glucose control. Dapagliflozin increases the removal of excess glucose through urine, Metformin reduces glucose production by the liver and improves insulin sensitivity, and Vildagliptin enhances the body’s incretin response to elevated blood glucose.

It is intended to be used alongside an appropriate diet, physical activity and the diabetes treatment plan selected by the doctor. The medicine is not a replacement for lifestyle measures or regular monitoring of blood glucose.

Uses

• Management of type 2 diabetes mellitus in adults.
• Helps lower elevated blood glucose when one or more medicines alone are insufficient.
• May be prescribed when treatment with Dapagliflozin, Metformin and Vildagliptin together is considered appropriate.
• Supports both fasting and post-meal blood-glucose control as part of an overall diabetes-management plan.

Key Benefits

• Combines three glucose-lowering medicines with complementary mechanisms.
• Dapagliflozin promotes urinary glucose excretion.
• Metformin improves the body’s response to insulin and reduces hepatic glucose production.
• Vildagliptin helps increase glucose-dependent insulin release and reduce inappropriate glucagon activity.
• Provides multiple blood-glucose-lowering actions in one tablet.

How to Use

• Take Daparyl-VM 500mg exactly as prescribed by your doctor.
• Swallow the tablet whole with water.
• Take it with food or at the time specified by your doctor to improve tolerability and follow the prescribed regimen.
• Do not crush, break or chew the tablet unless specifically instructed.
• Continue the medicine regularly even if your blood-glucose readings improve, unless your doctor changes the treatment.
• Follow the diet, exercise and blood-glucose monitoring plan recommended by your healthcare professional.
• Do not change the dose or stop treatment on your own.

How It Works

Daparyl-VM combines three different approaches to glucose control. Dapagliflozin blocks the SGLT2 transporter in the kidneys, reducing glucose reabsorption and allowing more glucose to leave the body in urine. Metformin mainly decreases glucose production by the liver and improves insulin sensitivity in peripheral tissues. Vildagliptin inhibits the DPP-4 enzyme, increasing the activity of incretin hormones that enhance insulin release when glucose is elevated and reduce glucagon secretion. These complementary actions help lower blood glucose through several physiological pathways.

Side Effects

• Nausea.
• Diarrhoea or stomach discomfort.
• Loss of appetite.
• Headache.
• Increased urination.
• Dehydration or thirst.
• Genital fungal infections.
• Urinary tract infections.
• Nasopharyngitis or cold-like symptoms.
• Dizziness.
• Weakness or fatigue.

Contact your doctor if side effects are persistent, severe or interfere with daily activities.

Precautions & Warnings

• Metformin can rarely cause life-threatening lactic acidosis, particularly in people with significant kidney impairment or other conditions that increase risk. Seek urgent medical attention for unusual weakness, persistent vomiting, abdominal discomfort, breathing difficulty, dizziness or feeling unusually cold. Kidney function should be assessed before and during treatment when appropriate.
• Dapagliflozin can cause diabetic ketoacidosis, which may occur even when blood glucose is not extremely high. Seek urgent medical attention for nausea, vomiting, abdominal pain, unusual tiredness, difficulty breathing or confusion, particularly during illness, prolonged fasting or reduced food intake.
• Dapagliflozin increases urinary glucose and can lead to dehydration and low blood pressure. Maintain adequate fluid intake unless your doctor has advised fluid restriction.
• Tell your doctor if you have kidney disease, recurrent urinary or genital infections, low blood pressure or are taking diuretics.
• Metformin may need to be withheld around certain iodinated contrast procedures depending on kidney function and the type of investigation. Inform the treating team before such procedures.
• Tell your doctor if you have liver disease or a history of abnormal liver-function tests, particularly because Vildagliptin may require liver-function monitoring.
• Vildagliptin has been associated with pancreatitis. Seek medical advice for persistent severe abdominal pain, particularly when accompanied by vomiting.
• Tell your doctor if you have a history of heart failure or other significant cardiovascular disease before using the combination.
• Alcohol can increase some risks associated with Metformin, including lactic acidosis, particularly with excessive intake.
• Tell your doctor about all medicines and supplements you take, including insulin and other glucose-lowering medicines, because combining treatments can increase the risk of hypoglycaemia.
• Inform your doctor if you are fasting, undergoing surgery or experiencing severe infection, vomiting or significant dehydration, as temporary treatment changes may be necessary.
• Consult your doctor before using Daparyl-VM during pregnancy or breastfeeding.
• Do not stop diabetes treatment abruptly without medical advice.
• Seek immediate medical care for severe abdominal pain, persistent vomiting, difficulty breathing, fainting, severe dehydration or symptoms of ketoacidosis.

Storage Instructions

• Store below 30°C.
• Keep the tablets in their original blister until use.
• Protect from moisture, excessive heat and direct sunlight.
• Keep the medicine in its original packaging.
• Keep out of reach and sight of children.
• Do not use the tablets after the expiry date printed on the package.

FAQs

Q: What is Daparyl-VM 500mg Tablet used for?
A: Daparyl-VM 500mg is prescribed to manage type 2 diabetes in adults as part of a broader treatment plan that includes appropriate diet and physical activity.

Q: What does Daparyl-VM 500mg contain?
A: Each tablet contains Dapagliflozin 10 mg, Metformin Hydrochloride 500 mg and Vildagliptin 100 mg.

Q: Is Daparyl-VM 500mg a prescription medicine?
A: Yes. Daparyl-VM 500mg is a prescription antidiabetic medicine and should be used under medical supervision.

Q: Can Daparyl-VM 500mg cause low blood sugar?
A: The individual ingredients have a relatively low risk of hypoglycaemia when used alone, but the risk can increase when Daparyl-VM is combined with insulin or certain other diabetes medicines. Follow your doctor’s instructions for blood-glucose monitoring.

Q: Why does Daparyl-VM increase urination?
A: Dapagliflozin causes more glucose to be removed through the urine. This can also increase urine volume and may contribute to dehydration in some people.

Q: Who manufactures Daparyl-VM 500mg Tablet?
A: Daparyl-VM 500mg Tablet is marketed by Intas Pharmaceuticals Ltd. Commonly listed presentations include 10- and 15-tablet packs.