Valparin Chrono 300mg Tablet

Description

Product Description

Valparin Chrono 300mg Tablet CR is a controlled-release formulation containing Sodium Valproate and Valproic Acid. Sanofi India Ltd. markets the Valparin Chrono range, and the 300 mg strength is commonly listed as a 15-tablet strip.

The two valproate components work together to stabilise abnormal electrical activity in the brain. Valproate increases the availability of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, and also influences voltage-gated ion channels involved in neuronal firing. By reducing excessive neuronal excitability, the medicine helps control seizures and may be used in selected mood disorders when specifically prescribed.

Uses

• Treatment and control of epilepsy.
• Management of different types of seizures when Sodium Valproate is clinically appropriate.
• May be used as part of long-term seizure management.
• May be prescribed for bipolar disorder or manic episodes in selected patients.
• Helps reduce abnormal electrical activity associated with seizure disorders.

Key Benefits

• Combines Sodium Valproate and Valproic Acid in one controlled-release tablet.
• Helps regulate excessive electrical activity in the brain.
• Provides prolonged drug release for prescribed treatment plans.
• Can be used for different seizure patterns when selected by a specialist.
• May have a role in mood stabilisation when specifically prescribed.

How to Use

• Take Valparin Chrono 300mg exactly as prescribed by your doctor.
• Swallow the tablet whole with water.
• Do not crush, chew or break the controlled-release tablet unless specifically instructed.
• Take it with or after food if that is how your doctor has prescribed it.
• Follow the same treatment schedule consistently.
• Do not stop treatment abruptly, even if you have remained seizure-free.
• If you miss a dose, follow your doctor’s or pharmacist’s advice rather than taking an extra dose on your own.

How It Works

Valparin Chrono works by reducing excessive electrical activity within the brain. Valproate increases inhibitory GABA signalling and also affects voltage-gated sodium and other ion channels that contribute to repetitive neuronal firing. These effects make neurons less likely to generate uncontrolled electrical discharges, which can help prevent seizures. Valproate also influences neurotransmitter systems involved in mood regulation, explaining its use as a mood stabiliser in selected clinical situations.

Side Effects

• Nausea or vomiting.
• Stomach discomfort.
• Diarrhoea.
• Tremor or shakiness.
• Sleepiness or drowsiness.
• Headache.
• Increased appetite or weight gain.
• Hair thinning or hair loss.
• Changes in menstrual pattern may occur in some patients.
• Changes in liver-function tests.
• Low platelet count or other blood-count abnormalities may occur.

Contact your doctor if side effects are persistent, severe or accompanied by unusual bleeding, marked weakness or other concerning symptoms.

Precautions & Warnings

• Valproate can cause serious birth defects and developmental disorders in babies exposed during pregnancy. It should not be used in women and girls of childbearing potential unless specialist medical assessment determines that alternatives are ineffective or not tolerated. Effective contraception and specialist review are required where valproate remains necessary. Contact your doctor urgently if you are pregnant, planning pregnancy or think you may be pregnant.
• Valproate can also cause serious liver injury and pancreatitis. Seek urgent medical attention for persistent vomiting, severe abdominal pain, loss of appetite, unusual tiredness, yellowing of the eyes or skin, or other signs of significant illness.
• Do not stop Valparin Chrono suddenly without medical advice because abrupt withdrawal can increase seizure frequency or precipitate serious seizures.
• Tell your doctor if you have liver disease, pancreatic disease, mitochondrial disorders or a history of significant blood abnormalities.
• Your doctor may recommend periodic liver-function tests, blood counts and other monitoring during treatment.
• Valproate can cause weight gain and changes in appetite; monitoring may be appropriate during longer-term use.
• Tell your doctor if you develop unusual bruising, bleeding, persistent weakness or frequent infections.
• Alcohol may increase drowsiness and should generally be avoided unless your doctor advises otherwise.
• Tell your doctor about all prescription medicines, over-the-counter products, vitamins and herbal supplements because Valproate has clinically important interactions with several medicines.
• Some other anti-seizure medicines can alter Valproate levels, while Valproate can also affect the levels or effects of other medicines.
• Consult your doctor before using Valparin Chrono during breastfeeding.
• Do not drive or operate machinery if you experience dizziness, drowsiness, tremor or impaired coordination.
• Seek immediate medical help for severe abdominal pain, persistent vomiting, jaundice, confusion, loss of consciousness, serious rash or unusual bleeding.

Storage Instructions

• Store below 30°C.
• Keep the tablets in their original blister until use.
• Protect from excessive heat, moisture and direct sunlight.
• Keep the medicine in its original packaging.
• Keep out of reach and sight of children.
• Do not use the tablets after the expiry date printed on the package.

FAQs

Q: What is Valparin Chrono 300mg Tablet used for?
A: Valparin Chrono 300mg is prescribed mainly for epilepsy and seizure control. Valproate may also be used as a mood stabiliser in selected patients when specifically prescribed.

Q: What does Valparin Chrono 300mg contain?
A: Each controlled-release tablet contains Sodium Valproate 200 mg and Valproic Acid 87 mg.

Q: Is Valparin Chrono 300mg a prescription medicine?
A: Yes. Valparin Chrono 300mg is a prescription medicine and should be taken under medical supervision.

Q: Can Valparin Chrono 300mg be stopped suddenly?
A: No. Abruptly stopping Valproate can increase seizure activity and may lead to serious complications. Any change in treatment should be planned with your doctor.

Q: Can Valparin Chrono 300mg cause weight gain?
A: Yes. Increased appetite and weight gain can occur in some people taking Valproate. Your doctor may monitor body weight during longer-term treatment.

Q: Who manufactures Valparin Chrono 300mg Tablet?
A: Valparin Chrono 300mg Tablet CR is marketed by Sanofi India Ltd. The commonly listed presentation contains 15 controlled-release tablets.